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The Ό63 patent discloses a synthesis of Vildagliptin using the synthetic process represented in Scheme 1. However, the preparation process of Vildagliptin intermediate, 1-chloro acetyl (S)-2- c ano pyrrolidine has some problems. The acylation of (S)-prolinamide of the formula. with chloroacetyl chloride of the formula.
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Short-term efficacy. It is well established that hyperglycemia, expressed as elevated HbA 1c, is associated with the risk of microvascular and macrovascular complications. Citation 11 Reduced rates of microvascular complications in well controlled type 2 diabetic patients were proven by prospective randomized trials. Citation 12, Citation 13 Thus the American Diabetes Association's.
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US-2017014379-A1 chemical patent summary.
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The present invention relates to a pharmaceutical formulation comprising therapeutically effective amount of vildagliptin or pharmaceutically acceptable salt thereof and a diluent. Particularly, the ratio of vildagliptin to diluent is in the range of 0.04 to 0.24 (w/w).
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Justia Patents US Patent Application for Pharmaceutical Formulations of Vildagliptin Patent Application (Application #20170014379) Pharmaceutical Formulations of Vildagliptin . Mar 5, 2015. The present invention relates to a pharmaceutical formulation comprising therapeutically effective amount of vildagliptin or pharmaceutically acceptable.
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Vildagliptin is an amino acid amide. Vildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are impaired. By inhibiting DPP-4, vildagliptin prevents the degradation of.
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Vildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are impaired. 2 By inhibiting DPP-4, vildagliptin prevents the degradation of glucagon-like peptide 1 (GLP-1) and.
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Patent Application Publication Jul. 10, 2008 US 2008/O167479 A1 O 630 560 49 2O 350 28 210 1400 I Illal. W -Wiwa Maa 2 34 39 44 49 54
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December 17, 2019 / 09:07 PM IST. The Rs 15,000 crore Indian anti-diabetes drug market is in for a shake-up as companies shift their focus towards promoting the latest generation of SGLT2.
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TR2010/10683A 2010-12-21 Vildagliptin formulations. The invention is a pharmaceutical formulation comprising vildagliptin granules having at least one coating layer and one or more excipients. More particularly, the invention relates to a tablet or capsule formulation of vildagliptin with a stable and desired level of solubility and dissolution.
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The invention is further defined with reference to the following clauses: 1. A combination of vildagliptin or a pharmaceutically acceptable salt thereof, and metformin or a pharmaceutically acceptable salt thereof, for use in a method of delaying loss of glycaemic control in a patient with type 2 diabetes mellitus. 2.
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The present invention relates to a process for preparing vildagliptin of formula (I) with high chemical and enantiomeric purity and compositions comprising vildagliptin. In addition, the present invention relates to (2S,2′S)-1,1′-[[(3-hydroxytricyclo[3.3.1.1 3,7 ]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]di(2-pyrrolidinecarbonitrile) of formula (II), processes for preparing, and.
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2.1. Patients. This was an observational PMS conducted in accordance with the Japanese Good Post-marketing Study Practice guidelines. Patients were centrally registered from April 2010 to April 2012 and were observed for up to 36 months until March 2015 across 775 clinics and hospitals throughout Japan.
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The present invention relates to a process for preparing vildagliptin of formula (I) with high chemical and enantiomeric purity and compositions comprising vildagliptin. In addition, the present invention relates to (2S,2′S)-1,1′-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]di(2-pyrrolidinecarbonitrile) of formula (II), processes for preparing, and compositions.
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Vildagliptin, sold under the brand name Galvus and others, is an oral anti-hyperglycemic agent (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin inhibits the inactivation of GLP-1 and GIP by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the islets of.
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Glucagon causes your liver to produce more sugar, so by reducing the amount of glucagon in your body, this also helps to reduce the levels of sugar in your blood. Vildagliptin can be used by itself or alongside other medicines for diabetes, to help control your blood sugar level in different ways. Vildagliptin is available in a combination.
