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Eperisone hydrochloride. Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex. It is not approved for use in the United States, but is available in other countries.
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Eperisone hydrochloride (4'-ethyl-2-methyl-3-piperidinopropriophenone hydrochloride) (Figure 1) is widely used for treatment of diseases with associated muscle stiffness and pain. In a trial in-volving 200 patients with myelopathy or spastic paraparesis, motor disability was significantly im-proved in 69.5% of patients by oral prednisolone.
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Eperisone is a medicine that works by relaxing both vascular smooth muscles and skeletal muscles, and demonstrates a variety of effects such as improvement of circulation, reduction of myotonia and suppression of the pain reflex. It improves tinnitus and dizziness associated with certain other disorders. It is also used as a supporting drug during initial stages of subsequent rehabilitative.
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No. Eperisone or eperisone hydrochloride is an antispasmodic medication and is used to relieve muscle stiffness and pain. It does not have a chemical structure or mechanism of action like steroids. Q. What is Eperisone Myonal? Myonal is the trade name for active medication Eperisone. It is an antispasmodic medication and is used to relieve.
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Relaxon adalah sediaan obat yang mengandung eperisone HCl. Obat Relaxon bekerja dengan melemaskan otot rangka, mengurangi kekuatan kontraksi otot, melebarkan otot polos pembuluh darah dan menambah aliran darah. Obat relaksan otot ini dapat meningkatkan sirkulasi darah dan menekan refleks nyeri sehingga rasa sakit dan tegang pada otot dapat.
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Reduction of muscle spindle sensitivity via Y-motor neurons: Eperisone hydrochloride suppresses the activity of afferent nerve fibers (Ia fibers) from human muscle spindles at 20 min. after administration. Eperisone hydrochloride suppresses the spontaneous discharge of Y-motor neurons, but does not act directly on muscle spindles in animals.
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The present method of Eperisone estimation was found to show a linearity with a coefficient of correlation (r 2) value 0.996-0.998 in a concentration range of 0.01 ng/ml to 10 ng/ml. The mean retention time of Eperisone in present study was 3.8 minutes with 0.01 ng/ml and 0.006 ng/ml as LLOQ and LOD, respectively.
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An 18-month-old child lost consciousness and had seizure, apnea and ventricular tachycardia after accidentally taking 100 mg of eperisone hydrochloride, which is equal to at least 1,000 to 2,000 mg eperisone in adults. 17 There were toxicity reports of QT prolongation, 18 torsades de pointes induced by severe QT prolongation after eperisone.
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A 65-year-old female with thoracic spinal stenosis and incomplete paraplegia underwent T11-T12 posterior thoracic interbody fusion. During postoperative rehabilitation, she experienced thigh pain, involuntary lower limb convulsions, and muscle fatigue. Despite being prescribed eperisone hydrochloride for relief, her muscle strength decreased after 14 doses. This adverse effect, not listed in.
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Introduction. Low back pain (LBP) is a common complaint and occurs in more than 80% of the population.1 It refers to an unpleasant sensory and emotional experience associated with actual or potential tissue damage felt near the mid-line in the lumbar or sacral region.2 The prevalence of low back pain is approximately 38.4%, more than one third among the productive age population.
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Eperisone hydrochloride (4′-ethyl-2-methyl-3-piperidinopropiophenone hydrochloride) is a muscle relaxant agent, widely used in the treatment of patients with muscular contractures, low back pain or spasticity. Because of its mechanism of action (inhibition of gamma-efferent firing and local vasodilatation activity), side effects on central nervous system are rarely observed. A sensitive.
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Chemical name: (2RS) 1 (4-Ethylphenyl)-2-methyl-3-piperidin-1-ylpropan-1-one monohydrochloride. Molecular formula: C 17 H 25 NO ⋅ HCl. Molecular weight: 295.85. Structural formula: Description: Eperisone hydrochloride occurs as a white, crystalline powder. It is freely soluble in water, in methanol and in acetic acid (100), soluble in ethanol.
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Deskripsi. EPERISONE TABLET merupakan obat yang mengandung Eperisone HCl. Eperisone HCl bekerja sebagai relaksan otot atau melemaskan otot rangka dan otot polos vaskular, yang menghasilkan pengurangan myotonia, peningkatan sirkulasi, dan penekanan refleks rasa sakit. EPERISONE digunakan untuk pengobatan simtomatik terhadap kondisi yang terkait.
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PDF | On Sep 12, 2021, Shukla Kavita and others published DESIGN, DEVELOPMENT OF FORMULATION OF EPERISONE HYDROCHLORIDE FLOATING SUSTAIN RELEASE TABLET AND ITS EVALUATION | Find, read and cite all.
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Eperisone hydrochloride (4'-ethyl-2-methyl-3-piperidinopropiophenone hydrochloride) is a muscle relaxant agent, widely used in the treatment of patients with muscular contractures, low back pain or spasticity. Because of its mechanism of action (inhibition of gamma-efferent firing and local vasodilatation activity), side effects on central.
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Improvement of muscular hypertonic symptoms in the following diseases: Cervical syndrome, periarthritis of the shoulder, lumbago. Spastic paralysis in the following disease: Cerebrovascular disease, spastic spinal paralysis, cervical spondylosis, postoperative sequelae (including cerebrospinal tumor), sequelae to trauma (spinal trauma, head injury), amyotrophic lateral sclerosis, cerebral.
