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PIM-2 kinase is expressed in hematopoietic cells and functions by phosphorylating various target substrates and thus subsequently affects cell survival, cell proliferation, transcriptional activation, and protein translation.. 21, 28, and 35 are shown (n = 14 mice per group).
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Pim-2 is a short-lived serine/threonine kinase, which plays a key role in metastasis of breast cancer through persistent activation of STAT3.. Bioorg Med Chem Lett 2011; 21: 6687-92. Article.
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Pim 2 is implicated in the DDR pathway in MM. (a) Transient KD of Pim2 in MM1.S cells was performed via transfection of siRNA. Cells were collected at 24 h after transfection and Western blotted.
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The serine/threonine kinase pim-2 was the most down-regulated of 9500 genes and ESTs between 0 and 12 h of IL-3 withdrawal ( p < 0.0005). This change in pim-2 expression was confirmed via Northern blot. The pim-2 transcript dropped within 6 h of cytokine withdrawal and was undetectable at 12 h ( Fig. 1A ).
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Various Pim substrates have been identified; Bad is phosphorylated by both Pim-1 and Pim-2 at Ser112 and this phosphorylation reverses Bad-induced cell apoptosis (11,12). Pim-2 is highly homologous to Pim-1 with similar oncogenic functions (13,14). Three isoforms of Pim-2 can be generated from alternative start sites which run at 34, 38, and 40.
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Pondok Indah Mall (Indonesian: Mal Pondok Indah), abbreviated as PIM, is a large shopping mall complex located in the Pondok Indah suburb of South Jakarta, Indonesia.In January 2017, it was recognised by Forbes as one of the top five shopping malls in Jakarta. The Pondok Indah Mall complex comprises three large main buildings, the older 3-storey PIM1 and the 5-storey PIM2, and the newest.
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In this study, we found that regulated by TNFα, Pim-2 proto-oncogene, serine/threonine kinase (PIM2) was highly expressed in HCC and correlated with poor prognosis (P = 0.007) as well as tumor.
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Pim-2 kinase exerts its oncogenic effects by phosphorylating target proteins involved in cell cycle and proliferation [19,20,21]. Pim-2 kinase phosphorylates BAD at serine 112 and reverses BAD-induced cell death . Pim-2 kinase is involved in the transduction of a variety of cellular signaling pathways, thereby promoting tumorigenesis.
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Pim-2 kinase is overexpressed in multiple myeloma (MM) cells to enhance their growth and survival, and regarded as a novel. 20 and activin A.21,22 Although Pim-2 appears to be an important.
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