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TORADOL (ketorolac tromethamine) is a member of the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAIDs). The chemical name for ketorolac tromethamine is ( )-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1), and the chemical structure is: Ketorolac.
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Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) used for short-term acute pain relief that requires opioid level of pain relief (analgesia). Ketorolac is not used for treating minor or chronic pain. Serious side effects include gastrointestinal bleeding, gastrointestinal perforation, congestive heart failure, heart attack (myocardial infarction), liver failure, kidney failure, and.
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Find patient medical information for ketorolac oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
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Ketorolac (Toradol) is a prescription non-steroidal anti-inflammatory drug (NSAID).It provides pain relief by blocking certain chemicals in your body that cause pain and inflammation. But ketorolac (Toradol) is meant for short-term use only due to the risk for severe side effects, such as heart attack and stomach ulcers.Typically, ketorolac (Toradol) is first given as an injection in a.
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The referred pharmaceutical composition may promote the acceleration of ketorolac pharmacological response. It is composed of tablets for sublingual administration containing from 2 to 15 mg of ketorolac or one of its pharmaceutically acceptable salts. The composition of the invention is particularly useful to obtain the rapid induction of.
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Intramuscular (IM): 30 mg as a single dose or 15 mg every 6 hours; not to exceed 60 mg/day. Oral: 10 mg once after IV/IM therapy, THEN 10 mg every 4-6 hours; not to exceed 40 mg/day. Children over 16 years, greater than 50 kg. Intravenous (IV): 30 mg as a single dose or 30 mg every 6 hours; not to exceed 120 mg/day.
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The recommended dose for oral administration is 10 mg every 4 to 6 hours, not exceeding 40 mg per day. Common side effects include rash, ringing in the ears, headaches, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation, heartburn, and fluid retention. Toradol, like most NSAIDs, is commonly associated with gastrointestinal.
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Mar-Ketorolac (Ketorolac Tromethamine Tablets) Page 5 of 49 arteriosus and prolonged parturition. Labour and delivery because, through its prostaglandin synthesis inhibitory effect, it may
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The mechanism of action of steroid drugs is similar, the action site is PG, arachidonic acid. Ketorolac tromethamine can relieve toxic pain of various muscles, soft tissues and joints. It is suitable for short-term treatment of acute and severe pain that requires opioid analgesics. It is usually used for postoperative pain, but not for mild or.
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The present invention refers to pharmaceutical compositions based on ketorolac or one of its salts pharmaceutically acceptable, as well as the use of ketorolac or one of its salts acceptable from pharmaceutical viewpoint, for preparation of a pharmaceutical composition (tablets) for sublingual administration, with the purpose of accelerating the pharmacological response to ketorolac, without.
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A pharmaceutical combination in the bilayer tablet form of immediate release comprising: i) a first layer containing between 1.0% and 6.0% w/w of ketorolac tromethamine; ii) a second layer containing between 4.0% and 11.0% w/w of tramadol hydrochloride; and iii) an optional coating that does not modify the release of the active pharmaceutical ingredients.
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The molecular weight of ketorolac tromethamine is 376.41. Its molecular formula is C 19 H 24 N 2 O 6. Ketorolac Tromethamine Tablets are white, round, biconvex, unscored, film-coated tablets. Each tablet, for oral administration, contains 10 mg ketorolac tromethamine, USP, the active ingredient.
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KETOROLAC TROMETHAMINE. PDF Supplier PDF. URL Supplier Web Content. US Patent Number. 9216167. Drug Substance Claim. Drug Product Claim. Patent Expiration Date. 2024-05-28.
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wherein said composition comprises ketorolac and sugar alcohol in a weight ratio of from about 0.3: 1.0 to about 1.0: 1.0. [0046] In an aspect of the above embodiments, the composition of the present application comprises water insoluble polymer in an amount of from about 30% to about 60% by weight of the composition.
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Ketorolac is used for the short-term relief of moderately severe pain and should not be used for longer than 5 days, for mild pain, or for pain from chronic (long-term) conditions. You will receive your first doses of ketorolac by intravenous (into a vein) or intramuscular (into a muscle) injection in a hospital or medical office.
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This medicine may raise the risk of heart and blood vessel problems like heart attack and stroke. These effects can be deadly. The risk may be greater if you have heart disease or risks for heart disease. However, it can also be raised even if you do not have heart disease or risks for heart disease. The risk can happen within the first weeks.