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Deskripsi Ketoconazole. Ketoconazole adalah obat yang bisa kamu gunakan untuk mengobati infeksi jamur serius tertentu di tubuh. Obat ini termasuk dalam golongan obat yang disebut antijamur azole. Cara kerjanya dengan membunuh dan menghentikan pertumbuhan jamur. Namun, obat tidak boleh digunakan untuk infeksi jamur pada kulit dan kuku karena.
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Ketoconazole side effects. Get emergency medical help if you have signs of an allergic reaction (hives, fever, chest pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).. Ketoconazole may cause serious side effects. Call your doctor at once if you have:
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Microbiology: Ketoconazole is a broad spectrum synthetic antifungal agent which inhibits the in vitro growth of the following common dermatophytes and yeasts by altering the permeability of the cell membrane: dermatophytes: Trichophyton rubrum, T. mentagrophytes, T. tonsurans, Microsporum canis, M. audouini, M. gypseum and Epidermophyton floccosum; yeasts: Candida albicans, Malassezia ovale.
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Berikut beberapa jenis penyakit jamur yang bisa diobati oleh ketoconazole: 1. Athlete's foot. Athlete's foot adalah sebuah kondisi medis yang disebabkan oleh infeksi jamur pada kulit di area kaki, terutama di antara jari-jari kaki. Gejalanya berupa gatal, kemerahan, sisik, serta terkadang terasa seperti terbakar pada kulit di sekitar kaki.
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Ketoconazole cream can help treat several different types of fungal skin infections. It's applied onto the skin and has very few side effects. This medication is only FDA approved for use in adults, since it isn't known if it's safe or works well in children. Reviewed by: Christina Aungst, PharmD. Last reviewed on February 2, 2023.
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Ketoconazole 1% shampoo is used to treat dandruff. Ketoconazole 2% shampoo is used to treat "sun fungus" (tinea versicolor; pityriasis versicolor). This medicine may also be used for other fungus infections of the skin as determined by your doctor. Most forms of this medicine are available only with your doctor's prescription.
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Dosis. PENGGUNAAN OBAT INI HARUS SESUAI DENGAN PETUNJUK DOKTER. Infeksi jamur sistemik: Dewasa : 200 mg 1 x sehari. Jika respon tidak ada, dapat ditingkatkan menjadi 400 mg. Anak > 2 tahun : 3,3-6,6 mg/kg 1 x sehari. Sindrom Crushing: Dewasa dan anak > 12 tahun: Dosis awal 400-600 mg, dapat ditingkatkan 200 mg per hari.
Chemical structure of Ketoconazole Download Scientific Diagram
Ketoconazole adalah obat antijamur jenis azole.Obat ini digunakan untuk mengobati infeksi jamur di kulit, seperti panu, kurap, kutu air, kandidiasis, dermatitis seboroik, dan ketombe yang berkaitan dengan jamur. Ketoconazole tersedia dalam bentuk krim, tablet, dan sampo. Ketoconazole bekerja dengan cara menghambat pembentukan ergosterol dan enzim tertentu yang dibutuhkan jamur untuk tumbuh dan.
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Farmakodinamik. Ketoconazole adalah obat azole oral pertama yang digunakan oleh klinisi untuk mengobati infeksi fungal. Ketoconazole bekerja dengan memblok sintesis dari ergosterol (salah satu komponen dari membrane sel fungal) melalui inhibisi pada sitokrom P-450 pada enzim lanosterol 14α - demetilase. [1,6] Karena enzim tersebut diinhibisi.
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Ketoconazole is also used to treat parasitic fungal infections on the skin (such as athlete's foot or ringworm) that cannot be treated with topical medicine or griseofulvin, or for patients who cannot take griseofulvin. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tablet.
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A bioavailablity of 76% has been reported for ketoconazole. Ketoconazole has an estimated volume of distribution of 25.41 L or 0.36 L/kg. It distributes widely among the tissues, reaching effective concentrations in the skin, tendons, tears, and saliva. Distribution to vaginal tissue produces concentrations 2.4 times lower than plasma.
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Ketoconazole did not show any signs of mutagenic potential when evaluated using the dominant lethal mutation test or the Ames Salmonella microsomal activator assay. Ketoconazole was not carcinogenic in an 18-month, oral study in Swiss albino mice or a 24-month oral carcinogenicity study in Wistar rats at dose levels of 5, 20 and 80 mg/kg/day.
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Ketoconazole is a prescription drug. It's available as an oral tablet, topical cream, topical foam, shampoo, and topical gel. The oral tablet is only available as a generic drug.
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KETOCONAZOLE (kee toe KON na zole) treats fungal or yeast infections. It belongs to a group of medications called antifungals. It will not treat colds, the flu, or infections caused by bacteria or viruses. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. COMMON BRAND NAME(S): Nizoral
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Ketoconazole is a drug used in the management and treatment of fungal infections. It is in the imidazole antifungal class of medications. This activity describes the indications, actions, and contraindications of ketoconazole as a valuable agent in treating fungal infections. This activity will highlight the mechanism of action, adverse event profile, and other key factors pertinent to members.
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This medicine is for use on the skin only. Do not get it in your eyes, nose, mouth, or vagina. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water. For patients using the cream: Apply enough cream to cover the affected and surrounding skin areas, and rub in gently.
