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Extracellular signal-regulated kinase (ERK) 1 and 2 serve an evolutionarily conserved role for intracellular signal transduction that proved critical for cardiomyocyte homeostasis and cardiac stress responses. Considering the importance of ERK1/2 in the heart, understanding how these kinases operate in both normal and disease states is critical.


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Effects of Phosphorylation of ERK2 Kinase on the Properties of Active Site Amino Acids Sun

To define the role of ERK1/2 signaling in the quiescent endothelium, we induced endothelial Erk2 knockout in adult Erk1 −/− mice. This resulted in a rapid onset of hypertension, a decrease in eNOS expression, and an increase in endothelin-1 plasma levels, with all mice dying within 5 wk. Immunostaining and endothelial fate mapping showed a robust increase in TGFβ signaling leading to.


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Protein kinases play a predominant regulatory role in nearly every aspect of cell biology [1].The human protein kinase family consists of 518 genes, which correspond to about 1.7% of the genome, thereby making it one of the largest gene families [2].Protein kinases catalyze the reaction illustrated in Fig. 1.Note that the phosphoryl group (PO 3 2−) and not the phosphate group (PO 4 2−) is.


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LOCTITE® EA 9396 AERO is a low viscosity, room temperature curing adhesive system with excellent strength properties at temperatures from -67°F to 350°F (-55°C to 177°C). LOCTITE EA 9396 AERO has a shelf life of one year when stored @ 77°F/25°C for separate components. Qualified to MMM-A-132, Rev A, Type 1, Class 3.


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The ERK1/2 catalyzed phosphorylation of nuclear transcription factors including those of Ets, Elk, and c-Fos represents an important function and requires the translocation of ERK1/2 into the nucleus by active and passive processes involving the nuclear pore. These transcription factors participate in the immediate early gene response.


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Extracellular signal-regulated kinase 1 (ERK1) and ERK2 relay cell growth and mitogenic signals to multiple substrates, and thus control essential physiological processes. This Review discusses.


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The extracellular signal-regulated kinase 1/2 (ERK1/2) belongs to an essential signaling pathway that regulates various stimuli-induced cellular processes, including cell proliferation.


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1. An Overview of ERK Signaling Components. Extracellular signal-regulated kinase 1/2 (ERK1/2) is a member of the "generic" mitogen-activated protein kinase (MAPK) signaling pathway [].The MAPK signaling pathway also includes among its members p38, MAPK, and c-Jun-N-terminal kinase 1/2/3 (JNK1/2/3).


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Signaling pathways are critical modulators of a variety of physiological and pathological processes, and the abnormal activation of some signaling pathways can contribute to disease progression in various conditions. As a result, signaling pathways have.


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The MEK-ERK pathway plays a role in DNA damage response (DDR). This has been thoroughly studied by modulating MEK activation. However, much less has been done to directly examine the contributions of ERK1 and ERK2 kinases to DDR. Etoposide induces G2/M arrest in a variety of cell lines, including MC.


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ERK2 (extracellular-signal regulated kinase 2, also known as p42 mitogen-activated protein kinase) is an integral member of the mitogen-activated protein kinase cascade that is crucial for many cellular events such as proliferation and differentiation. Here, we determined the genomic organization of the Erk2 gene and characterized its promoter. The Erk2 gene spans over 60 kilobases, and the.


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