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Drug-induced hypersensitivity syndrome (DIHS), also called drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, is a potentially fatal drug-induced hypersensitivity reaction that is characterized by a cutaneous eruption, multiorgan involvement, viral reactivation, and hematologic abnormalities.
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Introduction. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe adverse drug reaction classically associated with multiorgan involvement and often complicated by herpesvirus reactivation. 1 Mortality, dependent on patient age, underlying comorbidities, and the drug involved, occurs in up to 10% of patients and is typically.
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Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) that distinguishes it from other drug reactions is that viral reactivation characteristically follows onset of the disease. 1, 2, 3 It's clinical manifestations in multiorgans are highly heterogeneous and follow a variable and unpredictable course beyond the point where the causative.
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DrugInduced Hypersensitivity Syndrome (DIHS)/Drug Reaction With
Summary. Drug rash with eosinophilia and systemic symptoms, or DRESS syndrome, is a severe hypersensitivity reaction to certain medications. Symptoms of the condition include skin eruption, fever.
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Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome (DIHS/DRESS) is one example of a severe delayed T-cell mediated adverse drug reaction. DIHS/DRESS presents with fever, widespread rash and facial edema, organ.
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DrugInduced Hypersensitivity Syndrome (DIHS)/Drug Reaction With
Our understanding of the pathophysiology of DIHS/DRESS has evolved considerably over the last decade. DIHS/DRESS is distinguished from other drug eruptions by several characteristics, including the fact that it is associated with a limited number of causative drugs, exhibits late onset and a prolonged course, and patients' clinical symptoms deteriorate after treatment with the causative drug.
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Drug reaction with eosinphilia and systemic symptoms (DRESS) and drug-induced hypersensitivity syndrome (DiHS) represent the same spectrum of a drug reaction.To compare the clinical profile of patients diagnosed as definite/probable DRESS by the Registry.
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Synopsis. Drug-induced hypersensitivity syndrome (DIHS) is a potentially severe idiosyncratic drug reaction with systemic manifestations including fever, rash, and internal organ involvement, most typically hepatitis. The acronym DRESS, for drug reaction with eosinophilia and systemic symptoms, was proposed as a more specific term in 1996.
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INTRODUCTION. Drug-induced hypersensitivity syndrome (DIHS) was described in 1950 by Chaiken et al, 15 as the triad of fever, rash, and multiorgan failure occurring 1-8 weeks after an aromatic anticonvulsant drug had been started. Roujeau and colleagues 4,7,71 renamed the syndrome DRESS: drug rash with eosinophilia and systemic symptoms. Organ failure differentiates DIHS from other drug.
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Drug-Induced Hypersensitivity Syndrome (DIHS) is a severe and rare systemic reaction triggered by a drug (usually an antiepileptic drug). We present a case of DISH and we review studies on the clinical features and treatment of DIHS, and on its pathogenesis.
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Drug-induced hypersensitivity syndrome (DIHS), also called drug rash with eosinophilia and systemic symptoms (DRESS), is a severe reaction usually characterized by fever, rash, and multiorgan failure, occurring 1-8 weeks after drug introduction. It is an immune-mediated reaction involving macrophage and T-lymphocyte activation and cytokine.
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Drug-induced hypersensitivity syndrome (DIHS), including Stevens-Johnson syndrome (SJS), is a severe rash that often develops 2-6 weeks after the intake of the causative drug; however, its diagnosis is sometimes difficult. This article describes a case in which a patient with DIHS-induced multiple organ failure was successfully treated with blood purification therapy.
