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Clopidogrel comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take clopidogrel at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take clopidogrel exactly as directed.
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The typical dosage of clopidogrel is 75 milligrams (mg) taken once daily. For people with acute coronary syndrome, doctors typically recommend a one-time loading dose of 300 mg on the first day of.
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Clopidogrel oral tablet is a prescription drug that's available as the brand-name drug Plavix.It's also available as a generic drug. Generic drugs usually cost less than the brand-name version.
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Clopidogrel may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Your doctor may perform a blood test to make sure clopidogrel is right for you. This medicine is not expected to harm an unborn baby. However, taking clopidogrel within 1 week before childbirth can cause bleeding in the.
Clopidogrel a cosa serve e quali sono gli effetti collaterali?
2. Clopidogrel pharmacokinetics and pharmacodynamics. Following oral administration, about 50% of the dose is absorbed from the intestine based on urinary metabolites data [].Results from in vitro studies show that the uptake of clopidogrel into Caco-2 cells is limited by P-glycoprotein (P-gp, ABCB1), which suggests that P-gp may affect the intestinal absorption and oral bioavailability of.
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Side Effects. Easy bleeding/bruising, stomach upset/pain, diarrhea, and constipation may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that.
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Oral: 75 mg once daily in combination with aspirin; duration of clopidogrel depends on degree of stenosis. Stenosis of 50% to 69%: Clopidogrel may be added to aspirin for 21 days; after 21 days, discontinue clopidogrel and continue aspirin indefinitely (Ehtisham 2019).
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Clopidogrel merupakan pengencer darah, yang bekerja dengan menghambat pelekatan trombosit dan penyumbatan berbahaya. Clopidogrel digunakan untuk mengurangi kejadian trombolitik pada infark miokard yang belum lama terjadi, stroke, atau penyakit arteri perifer, sindrom koroner akut.
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Clopidogrel termasuk kategori obat yang memiliki sifat polimorfisme. Dua bentuk polimorfik Clopidogrel telah diidentifikasi dan ditetapkan sebagai Form 1 dan Form 2. Form 1 dan Form 2 memiliki indikasi yang sama. Perbedaan antara dua bentuk kristal terletak pada susunan kation Clopidogrel dan anion sulfat.
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Methods. The study included patients receiving either a single 300 mg loading dose of clopidogrel (n = 17) or a 75 mg dose (n = 45) for at least 7 days before sample collection.The concentrations of clopidogrel and its metabolites—the inactive H3 and the pharmacologically active H4 isomers of the thiol metabolite and the inactive carboxylic acid metabolite—in plasma samples (stabilized.
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Obat ini juga digunakan dengan aspirin untuk bantu mengobati memburuknya nyeri dada (serangan jantung baru, tidak stabil angina), menjaga pembuluh darah terbuka, serta mencegah pembekuan darah pasca-prosedur tertentu (misalnya stent jantung).
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Absorption. A 75mg oral dose of clopidogrel is 50% absorbed from the intestine. 9 Clopidogrel can be taken with or without food. 9 A meal decreases the AUC of the active metabolite by 57%. 9 The active metabolite of clopidogrel reaches a maximum concentration after 30-60 minutes. 9 Clopidogrel reached a C max of 2.04±2.0ng/mL in 1.40±1.07h. 5 The AUC for a 300mg oral dose of clopidogrel was.
