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Clopidogrel is FDA approved for the medical management of unstable angina (UA)/non-ST-segment elevation myocardial infarction (NSTEMI), ST-segment elevation myocardial infarction (STEMI) in patients receiving fibrinolytic therapy, and for secondary prevention in recent myocardial infarction (MI), recent stroke, and peripheral arterial disease. There also a number of other FDA-approved uses.
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Side Effects. Easy bleeding/bruising, stomach upset/pain, diarrhea, and constipation may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that.
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Generic Name Clopidogrel DrugBank Accession Number DB00758 Background. Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. 3,9 Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or.
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Clopidogrel drug interactions: a review of the evidence and clinical implications. doi: 10.1080/17425255.2020.1814254. inhibitor, is a topic of potential clinical concern. This article reviews DDIs between clopidogrel and drugs which are widely used in clinical practice. In particular, drugs shown to interfere with the pharmacodynamic and.
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Key takeaways: Clopidogrel is a medication that prevents blood clots from forming. This can lower the risk of heart attack and stroke. Medications like proton pump inhibitors (PPIs), fluoxetine (Prozac), and fluconazole (Diflucan) can make clopidogrel less effective. Grapefruit juice can also make clopidogrel less effective.
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The way clopidogrel works is thought to be due to its active thiol metabolite, which inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor which indirectly inhibits platelet aggregation. This action is irreversible. By inhibiting platelet aggregation, blood flows more freely around the body.
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Clopidogrel, a prodrug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y₁₂ adenosine diphosphate (ADP) receptor, decreasing platelet activation and aggregation processes. Atorvastatin, omeprazole, and several other drugs have been shown in pharmacodynamic studies to.
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The DDI profiles of clopidogrel have been reviewed by Egan et al, Shah et al, Siller-Matula et al and Scott et al.7-10 However, these authors only addressed the circumstances under which DDIs occurred when clopidogrel was the object drug or focused on combination therapy with clopidogrel and special classes of medications, such as.
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Multidrug therapy increases the risk for drug-drug interactions. Clopidogrel, a prodrug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y 12 adenosine diphosphate (ADP) receptor, decreasing platelet activation and aggregation processes. Atorvastatin, omeprazole, and several other drugs have been shown in.
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It comes as a tablet taken by mouth once per day and is also available as a generic medication. Since it's a blood thinner, possible side effects include bleeding and bruising, especially if you take medications that interact with clopidogrel (Plavix) like certain antidepressants, anticoagulants, or non-steroidal anti-inflammatory drugs (NSAIDs).
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Clopidogrel oral tablet is a prescription medication used to prevent heart attack or stroke. It works by preventing blood clots, which it does by keeping platelets in your blood from sticking.
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Clopidogrel remains the most widely prescribed P2Y 12 inhibitor worldwide, largely related to clinician familiarity and affordability. Given frequent co-administration of clopidogrel and PPI therapy, their common hepatic metabolism, and the consequences of suboptimal therapeutic effects, clarifying a possible adverse pharmacological interaction.
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Clopidogrel may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Your doctor may perform a blood test to make sure clopidogrel is right for you. This medicine is not expected to harm an unborn baby. However, taking clopidogrel within 1 week before childbirth can cause bleeding in the.
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Defibrotide. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abciximab. Aceclofenac. Acemetacin. Alfentanil.
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Clopidogrel Interactions. There are 249 drugs known to interact with clopidogrel, along with 3 disease interactions. Of the total drug interactions, 64 are major, 168 are moderate, and 17 are minor.
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Clopidogrel comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take clopidogrel at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take clopidogrel exactly as directed.
