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Ceftizoxime. Ceftizoxime adalah antibiotik yang digunakan untuk mengobati berbagai penyakit akibat infeksi bakteri, seperti gonore dan infeksi saluran kemih. Obat ini hanya dapat digunakan dengan resep dokter. Ceftizoxime termasuk antibiotik golongan sefalosporin generasi ketiga yang tersedia dalam bentuk suntik.
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Note: Cefizox (ceftizoxime for injection, USP) in the ADD-Vantage® vial is intended for intravenous infusion only after dilution with the appropriate volume of ADD-Vantage diluent solution. The usual adult dosage is 1 or 2 grams of Cefizox (ceftizoxime for injection, USP) every 8 to 12 hours. Proper dosage and route of administration should be.
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Ceftizoxime is an iminomethoxy aminothiazolyl cephalosporin that inhibits a wide variety of aerobic, anaerobic gram-positive and gram-negative bacteria. The majority of Enterobacteriaceae are inhibited by less than or equal to 1 microgram/ml as are streptococcal species with the exception of Strepto.
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Ceftizoxime concentrations are higher in cord blood and AF than in maternal blood, perhaps because of more avid binding to fetal serum proteins. It is the only antibiotic known to have such high transfer. Rodent studies are reassuring, revealing no evidence of teratogenicity or IUGR despite the use of doses higher than those used clinically..
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Ceftizoxime. Sharon S. Castle, in xPharm: The Comprehensive Pharmacology Reference, 2007 Therapeutics. Ceftizoxime is active against gram-positive and a wide range of gram-negative organisms, excluding pseudomonas. Staphylococcal coverage lessens in this third-generation group. Ceftizoxime is used for the treatment of meningitis, lower respiratory infections, urinary tract infections, pelvic.
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This chapter provides basic characteristics, FDA- approved indications, side effects/toxicity, dosage information, drug/food interactions and antimicrobial therapy art of CEFIZOX (Ceftizoxime). Ceftizoxime is used for treatment of patients with infections caused by susceptible strains of organisms in the following diseases: lower respiratory.
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fever, chills, body aches, flu symptoms; easy bruising or bleeding, unusual weakness; fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; seizure (black-out or convulsions); or. jaundice (yellowing of the eyes or skin). Less serious side effects are more likely to occur, such as:
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Mechanism of action. Ceftizoxime is an aminothiazolyl cephalosporin with an extended spectrum of activity against many gram-negative, nosocomially acquired pathogens. It has excellent beta-lactamase stability, with good in vitro activity against Haemophilus influenzae, Neisseria gonorrhoeae and Klebsiella pneumoniae.
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Cefizox (ceftizoxime injection) in the Galaxy ® plastic container is a frozen iso-osmotic, sterile, nonpyrogenic premixed 50 mL solution containing 1 g or 2 g of ceftizoxime as ceftizoxime sodium. Dextrose, USP has been added to these dosages to adjust osmolality (approximately 1.9 g and 950 mg to the 1 g and 2 g dosages as dextrose hydrous, respectively).
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Ceftizoxime is a 'third generation' cephalosporin administered intravenously or intramuscularly. Like other third generation cephalosporins it has a wide spectrum of in vitro activity against Gram-positive and Gram-negative bacteria, is particularly active against Enterobacteriaceae (including beta-lactamase-positive strains), and is resistant to hydrolysis by beta-lactamases.
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The usual adult dosage is 1 or 2 grams of Cefizox (ceftizoxime injection) in Galaxy ® plastic container every 8 to 12 hours. Proper dosage and route of administration should be determined by the condition of the patient, severity of the infection, and susceptibility of the causative organisms. General Guidelines for Dosage of Cefizox.
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Ceftizoxime is a parenteral, third-generation cephalosporin antibiotic used to treat bacterial infections including ear, nose, and throat infections. These pectin-based nanocarriers were spherical with a size range of 70 to 90 nm where the drug molecule is entrapped within the pectin gel.
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CEFIZOX® SmithKline Beecham . Ceftizoxime Sodium . Antibiotic . Action And Clinical Pharmacology: In vitro studies indicate that the bactericidal action of ceftizoxime results from inhibition of cell-wall synthesis in aerobic and anaerobic gram-positive and gram-negative organisms. In vitro, ceftizoxime shows a strong affinity for penicillin-binding proteins 1a, 1bs and 3 of E. coli.
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Synopsis: Ceftizoxime 1 is a 'third generation' cephalosporin administered intravenously or intramuscularly. Like other third generation cephalosporins it has a wide spectrum of in vitro activity against Gram-positive and Gram-negative bacteria, is particularly active against Enterobacteriaceae (including β-lactamase-positive strains), and is resistant to hydrolysis by β-lactamases.
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Ceftizoxime is a third-generation cephalosporin available for parenteral administration. [1] Unlike other third-generation cephalosporins, the whole C-3 side chain in ceftizoxime has been removed to prevent deactivation by hydrolytic enzymes . It rather resembles cefotaxime in its properties, but is not subject to metabolism.
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Patel et al. compared the serum bactericidal titers (SBTs) and the time serum drug concentrations remained above the MICs (T > MIC) of ceftizoxime and cefotaxime against three intermediately penicillin-resistant Streptococcus pneumoniae isolates.MICs were ≤ 1.0 μg/ml, SBTs were > 1:2, and T > MIC exceeded 50% of dosage intervals. They concluded that ceftizoxime's longer T > MIC.