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Il progetto bioMILD è una ricerca innovativa per la prevenzione e la diagnosi precoce del tumore polmonare. Scopri come partecipare, quali sono i benefici e i rischi, e quali sono le strutture sanitarie coinvolte. Visita il sito biomild.org e fai il primo passo per la tua salute.
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The bioMILD trial prospectively enrolled 4,119 volunteers at Istituto Nazionale Tumori of Milan with the median age of 60 years, median pack-years 42, current smokers 79% and females 39%. At the end of March 2019, a total of 11,012 LDCTs and 9,156 miRNA tests were performed, with an overall compliance at the 3-year LDCT of 93% and a median.
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However, validation and reproducibility studies are necessary for the implementation of this strategy proposed by the BioMILD trial. In addition, the employment of miRNAs as a minimally invasive tool together with CT in lung cancer screening programs still needs to be better addressed, especially due to conflict data about these biomarkers in.
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Katherine Richeson, who oversees product development at Biomilq, is a cell biologist who conducted research on cancer therapies, including breast-cancer treatment, prior to coming to the company.
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The BioMILD study was launched in 2013 to evaluate whether a blood MSC assay at the time of baseline LDCT improves predictive ability in detecting LC (main aim). The primary endpoint was the proportion of LC detected within the third year screening round (i.e. 4-year LC incidence) in the entire population entering the study. Secondary end-
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On 18 March 1996, Campina, which produces milk products, applied to the BTMO for registration of the composite word BIOMILD as a trade mark in respect of goods in Classes 29, 30 and 32 of the Nice Agreement concerning the International Classification of Goods and Services for the Purposes of the Registration of Marks of 15 June 1957, as revised.
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The bioMILD trial prospectively enrolled 4,119 volunteers at Istituto Nazionale Tumori of Milan with the median age of 60 years, median pack-years 42, current smokers 79% and females 39%. At the.
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The BioMILD trial offered a lung cancer screening program combining low-dose CT and blood microRNA assay to heavy smokers (current or former ≤ 10 years) aged 50-75 years old. At baseline, low-dose CT and microRNA were tested independently with blind evaluation. According to low-dose CT and microRNA profile, different screening intervals.
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BioMILD is a prospective trial that offered heavy smokers a screening program combining a high threshold for negative LDCT (113 mm 3) and a predefined blood miRNA assay (MSC). At baseline, LDCT and the MSC were tested independently in 4119 volunteers with blind evaluation, with different screening intensities according to the results of the two.
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The primary aim of the prospective BioMILD study was to assess the additional value of the blood MSC assay at the time of baseline LDCT with the goal of personalizing LC screening intervals. Patients and methods: The study enrolled 4119 volunteers from January 2013 to March 2016, with a median follow-up of 5.3 years.
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Focusing on the 655 LDCT + BioMILD participants at the baseline, lung cancer was diagnosed within the first 2 years in 38 of the 209 (18%) MSC-positive and 28 of 446 (6%) MSC-negative participants. By performing the ISC test in MSC-negative subjects only, 24 of the 28 (86%) malignant nodules could be recovered by ISC at the cost of 105 of 418.
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"BioMild showed that the combination of microRNA assay and LDCT is a valuable and safe tool to assess individual risk profile and reduce unnecessary LDCT repeats in lung cancer screening," said Dr.
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L'adesione al progetto bioMILD è volontaria e completamente gratuita. Si può aderire: compilando l'apposito modulo di inviando una mail all'indirizzo [email protected] telefonando al numero verde 800 213 601 telefonando al numero 02 2390 2913. Tumore al polmone: una diagnosi precoce dall'analisi del sangue